A study on the implementation of hospital information system and degree of job satisfaction is available but not widely deployed. The purposes of this study are to analyze level of hospital information system in selected secondary, tertiary hospital and to compare convenience, degree of information applicability, willingness of participation, degree of job satisfaction after implementation of hospital information system by each department and to consider factors influencing degree of job satisfaction. Two secondary hospitals and four tertiary hospitals are participated and two sets of questionnaires are used for this study. Convenience and degree of information applicability are significant by each department. Convenience, degree of information applicability, willingness of participation are major factors in improving degree of job satisfaction after implementation of hospital information system.