Current and new emerging applications of telemedicine system will require the use of computers capable of supporting a wide variety of multimedia information. In addition, the advancement of powerful personal computer, diverse media acquisition units and wide bandwidth communication network has enabled the design and development of cost-effective multi-media telemedicine system integrated on a personal computer. In this paper, we present the design methods for PC-based multimedia telemedicine system, which includes patient medical records, radiological images, biological data, medical moving images and video-conferencing. The main strategies of that system are cost-effectiveness, open standards and inclusion on diverse set of medical modalities.