A prescription issuing system is computerized in so many hospital. While the shareable and usability of an electronic prescription is increased by computerized materials, it can be serious for an information about a patient to be exposed in public. In this paper, the proposed system to issue an electronic prescription is aimed to keep using the existing paper-based prescription issuing system and extend the system using by IC card. It is developed for the secure method of an electronic prescription to transfer between hospital and pharmacy. For this, in this paper, it is defined for the standard minimal data set of a prescription information and developed the method to store the electronic prescription to IC card. It is set the access authority to access the electronic prescription stored in IC card by classifying the access authority group. Since the security and certificate authority center is established using Windows 2000, the electronic prescription stored in IC card can be secured and certificated by an encryption, decryption and digital signature. Lastly, the terminal and server system transferred an electronic prescription of a hospital and a pharmacy is implemented. The proposed system in this paper is simulated in some hospital and pharmacy. On the result of simulation, it is hoped for increasing the prescription transferring service, because the proposed transfer system of an electronic prescription using IC card is stable, secure, available, and creditable.