Bioinformatics is a rapidly emerging field of biomedical research. A flood of large-scale genomic, proteomic and postgenomic data means that many of the challenges in biomedical research are now challenges in informatics. Clinical informatics has long developed technologies to improve biomedical research and clinical care by integrating experimental and clinical information systems. Biomedical informatics, powered by high throughput technologies, genomic-scale databases, and advanced clinical information system, is likely to transform our biomedical understanding forever much the same way that biochemistry did to biology a generation ago. The emergence of health and biomedical informatics revolutionizing both bioinformatics and clinical informatics will eventually change the current practice of medicine, including diagnostics, therapeutics, and prognostics.